POLYDRUG DEPENDENCE By N., Pam M.S. - April 7, 2013 dependency on more than one drug of abuse. Commonly referred to as polysubstance dependence. POLYDRUG DEPENDENCE: "Her polydrug dependence has led to severe weight loss and the demise of her career and many interpersonal relationships." Related Psychology Terms PSYCHOLOGICAL DEPENDENCE PHYSICAL DEPENDENCE AMPHETAMINE POLYDRUG ABUSE CANNABIS DEPENDENCE CARISOPRODOL DEPENDENCY NEEDS OPIOID AGONIST TOLERANCE SEDATIVE, HYPNOTIC, OR ANXIOLYTIC ABUSE Cite this page: N., Pam M.S., "POLYDRUG DEPENDENCE," in PsychologyDictionary.org, April 7, 2013, https://psychologydictionary.org/polydrug-dependence/ (accessed April 8, 2020).