Written by Pam MS, NCSP | Fact checked by Psychology Dictionary staff 

Nutritional supplement marketed under the Gumbaral, Samyr, Adomet, Heptral and Admethionine brand names as a prescription drug approved in Russia, Italy, and Germany. Preliminary research suggests SAM may have therapeutic potential in treating Alzheimer's patients and a recent study using a mouse model of Alzheimer's found that supplementary SAM prevented oxidative damage and cognitive impairment.

S-ADENOSYLMETHIONINE (SAM): "The doctor prescribed S-adenosylmethionine to help with her depression."

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