significant anxiety (e.g., generalized anxiety, panic attacks, obsessions, and compulsions) that interferes with daily functioning, and is deemed to be caused directly by the physiological effects of a general medical condition. Anxiety of this type is caused by a number of medical conditions, including endocrine disorders (e.g., hyperthyroidism), respiratory disorders (e.g., chronic obstructive pulmonary disease), and cardiovascular disorders (e.g., arrhythmia).