n. a protein enzyme (protease) which cleaves the amyloid precursor protein to form beta-amyloid. These are the peptides which build-up to create plaque in the walls of vessels and parenchymal tissues of the brain. This protease, therefore, plays a crucial role in Alzheimer's disease.

BETA-SECRETASE (P-SECRETASE): "Beta-secretase (P-secretase) is that protein enzyme which leads to the production of beta-amyloid."
Cite this page: N., Pam M.S., "BETA-SECRETASE (P-SECRETASE)," in, April 7, 2013, (accessed May 13, 2021).