DOWN-REGULATION By N., Pam M.S. - April 7, 2013 The decrease in the number of receptor molecules in an area. See up-regulation. DOWN-REGULATION: "Down regulation means there are less receptor molecules in the area." Related Psychology Terms MAOIS UP-REGULATION ALLOSTERIC MODULATION NMDA RECEPTOR RECEPTOR SITE LOCK-AND-KEY THEORY IONOTROPIC RECEPTOR DISUSE SUPERSENSITIVITY MELANOCORTIN-4 RECEPTOR (MC4-R) PHASIC RECEPTOR Cite this page: N., Pam M.S., "DOWN-REGULATION," in PsychologyDictionary.org, April 7, 2013, https://psychologydictionary.org/down-regulation/ (accessed November 28, 2020).