The theory that decreased activity of the excitatory neurotransmitter glutamate is responsible for the clinical expression of schizophrenia. Developed by observing symptoms induced by phencyclidine that act as antagonists at NMDA receptors.

GLUTAMATE HYPOTHESIS: "The glutamate hypothesis deals with a possible role in schizophrenia."
Cite this page: N., Pam M.S., "GLUTAMATE HYPOTHESIS," in, May 11, 2013, (accessed October 14, 2020).