Written by Pam MS, NCSP | Fact checked by Psychology Dictionary staff 

a type of drug tolerance wherein the chemistry of the brain comes to be acclimated to the existence of the drug, that in turn then loses its ability for changing brain activity. Neurons acclimate to ongoing drug presence by lessening the amount or vulnerability of receptors accessible by the drug . This cellular-adaptive tolerance is correlated with the utilization of multiple drugs, inclusive of sedative hypnotics and psychostimulants, and might be trailed by symptoms of withdrawal whenever typical dosages of the drug are disrupted.

PHARMACODYNAMIC TOLERANCE: "The doctor says Brittney has developed a pharmacodynamic tolerance."

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