noun. 1. a condition, stemming from continual utilization of a drug, marked by a significant lessened impact with regular use of the same dosage of the drug or via a need to up the dosage significantly over time to reach the same favored impact. Tolerance is one of the two prime symptoms of physical dependence on a drug, the other being a characteristic withdrawal syndrome. 2. acceptance of others whose actions, beliefs, physical capacities, religion, morals, traditions, ethnicity, nationality, and so on vary from one
TOLERANCE: "Tolerance is commonly observed in alcoholics."