was first isolated from the tobacco plant in 1828 and was then named after the French diplomat, Jean Nicot, who introduced tobacco into France. Nicotine is one of the most widely distributed and used psychoactive drugs available. Ingestion of nicotine can result in the following symptoms: a sudden release of glucose, an increase in blood pressure, respiration, heart rate, and cutaneous vasoconstriction) and the dependence that develops (see dependence- withdrawal). Nicotine has a number of effects on the nervous system of humans, for example it activates the nicotinic receptors which then facilitate several neurotransmitters, this process will explain the euphoric feeling some smokers obtain.