ZOFRAN By Nugent, Pam M.S. - April 29, 2013 noun. a brand name for ondansetron. ZOFRAN: "Zofran is often prescribed for people on high doses of medication or those who have just had surgery with significant amounts of anesthesia, in effort to lessen nausea caused by said drugs." Related Psychology Terms BRAND LOYALTY THORAZINE ZELMID VESTRA ZYDIS PARLODEL DDAVP DARVON AMYTAL ZOMARIL Cite this page: Nugent, Pam M.S., "ZOFRAN," in PsychologyDictionary.org, April 29, 2013, https://psychologydictionary.org/zofran/ (accessed May 26, 2018).